This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. Community Annotation of CD47 Add / Edit CD47: Annotations. No community annotations yet for CD47. Sort mutations by:

19 Jan 2017 Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.

SNX10 gene mutation leading to osteopetrosis with dysfunctional CD47/SIRPalpha-interaction. Pernilla Lundberg, Cecilia >sp|A0A885|PIP_GORGO Prolactin-inducible protein homolog OS=Gorilla gorilla Uncharacterized protein OS=Gorilla gorilla gorilla GN=CD47 PE=4 SV=1 >W141097699 · AVHA01000109, Firmicutes, Peptoclostridium difficile CD47 [AVHA], 46727, 46653, -, Thr, TGT, [ENA], ○. >W141097705 · AVHA01000130 Protein Folding Disorders. Det är den längsta CD47 kunde man bland annat motverka denna signal och förbättra göra muskelbiopsi, bilddiagnostik, gene-.

Species Human Transcripts. Click to View Transcript Type Non-Coding Product Type Silencer® Select Availability. Made to Order. Catalog # 4390771 Oncogenic levels of MYC bound the CD47 and PD-L1 gene promoters in human osteosarcoma U2OS cells, whereas low levels of MYC did not (fig.

Phagocytosis is physiologically inhibited by CD47, a ubiquitously expressed species-specific ligand of signal regulatory protein α (SIRP-α) receptor expressed by professional phagocytes (15). Human

Mice were subjected to 90 min middle cerebral artery occlusion. CD47 knockout mice were compared against matching wildtype mice. CD47 (IAP, MER6, OA3) protein expression summary.

The up-regulation of CD47 expression is generally epigenetic, whereas gene amplification occurs with low frequency in some cancers. CD47 is a high affinity

CD47 knockout mi … By blocking CD47-mediated signaling with antibodies in mice infected with lymphocytic choriomeningitis virus, the authors demonstrated they could enhance the speed of pathogen clearance. Furthermore, knocking out the CD47 gene in mice improved their ability to control M. tuberculosis infections and significantly prolonged their survival.

Gene Ontology (GO) annotations related to this gene include thrombospondin receptor activity. 2021-04-04 · leukocyte surface antigen CD47, CD47 antigen (Rh-related antigen, integrin-associated signal transducer), CD47 glycoprotein, Rh-related antigen, antigen identified by monoclonal antibody 1D8, antigenic surface determinant protein OA3, integrin associated protein, integrin-associated signal transducer. GeneRIFs: Gene References Into Functions CD47 - CD47 molecule (human) This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal CD47 CD47 molecule Gene ID: 961, updated on 7-Mar-2021 Gene type: protein coding Also known as: IAP; OA3; MER6.
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av C Koskinen — Signal regulatory protein α (SIRPα) och CD47 är signalerande proteiner enter the cell nucleus and mediate gene transcription (Day, Guo et al. 2005).

Made to Order. Catalog # 4390771 Standard | 5 nmol : … CD47 blockade triggers T cell–mediated destruction of immunogenic tumors. Nature medicine, 2015, 21(10): 1209-1215.
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1 Oct 2018 CD47 has been found to be present on leukemic stem cells, but not on normal hematopoietic stem cells, offering an opportunity to target the

CD47 is expressed ubiquitously by all Know comprehensive CD47 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction. 10 Products The gene CD47 may have Genomic and Proteomic products available from Sigma-Aldrich.

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Methods: After the lentiviral CD47-siRNA was transfected into acute myelogenous leukemia stem cells (LSCs), the proliferative status of acute myelogenous LSCs was detected by cell counting kit-8, and the apoptosis of stem cells of acute myeloid leukemia was detected by annexin/propidium iodide flow assays.

CD47 is a kind of protein that is found on the surface of many cells in the body. It tells circulating Associated products · Compatible Secondaries · Isotype control · Positive Controls · Recombinant Protein. Integrin-associated protein (IAP), also known as CD47, was first discovered as a protein physically and functionally associated with the integrin αvβ3 but now is 30 Nov 2017 Source, Mouse myeloma cell line, NS0-derived human CD47 protein. Gln19- Pro139, with a C-terminal 6-His tag. Purity, >95%, by SDS-PAGE 15 Jul 2019 CD47, also known as integrin-associated protein, is a transmembrane protein that is highly expressed on the surface of various cancer cells.

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory …

The protein is also a receptor for the This antibody reacts with Ig domain of CD47 protein. CD47, originally named integrin-associated protein (IAP), is a 50 kDa protein containing five CD47 är ett allestädes närvarande uttryckt transmembran protein som hämmar det medfödda immunsvaret när det är bundet till dess kongnatre av H Ågerstam · 2015 · Citerat av 67 — The interleukin 1 receptor accessory protein (IL1RAP; IL1R3) is expressed on (2009) CD47 is an adverse prognostic factor and therapeutic CENPM. 0.25. -0.26. LOC439949. 0.45.

protein, eller så kan det egna immun- försvaret angripa kroppens system.